Assoc. Scientific Director – Antibody Engineering

Assoc. Scientific Director – Antibody Engineering

Requirements

• BS/BA in Analytical Chemistry or related discipline and 10+ years of experience in pharmaceutical research or development OR
• MS/MA in Analytical Chemistry or related discipline and 8+ years of experience
• PhD in Analytical Chemistry or related discipline and 5+ years of relevant experience; may include postdoc experience
• Previous managerial / functional management experience also required
• Industry leading knowledge of state-of-the-art protein engineering concepts and techniques
• Practical experience with affinity determination methods, and execution of antibody optimization campaigns using directed evolution screening platforms
• Protein expression, purification and analysis
• Gene manipulation techniques, including cloning, and use of gene expression manipulation technologies (ASO, siRNA, miRNA, AAV transduction)
• MAbs/bi specifics – Proven success in the ability to apply protein engineering principles to mAb & BiSp design
• Knowledge of immunogenicity & antibody effector assays
• Advanced knowledge of protein structure function relationships
• Ability to utilize bioinformatics software for protein and gene analyses
• Excellent interpersonal skills with strong oral and written communication abilities
• Excellent laboratory skills and proven productivity
• Method development, validation, and transfer experience in process development a plus
• Expert knowledge of cross-functional understanding related to drug development
• Proven strong track record in advanced experimental technologies and their utilization in the drug discovery process
• Experience with delivery of biologics across the blood brain barrier a plus
• Excellent critical analysis skills
• Assimilates data and research findings outside of Neurocrine for application to new scientific projects
• Maintains broad knowledge of scientific principles and theories and possesses intellectual mastery of one or more scientific areas
• Develops an understanding of other areas and related dependencies
• Advanced knowledge and demonstrated ability working with / recommending a variety of laboratory equipment/tools
• Strong ability to work as part of and lead multiple teams
• Excellent leadership skills and ability, typically leads multi-level teams and/or indirect teams
• Excellent computer skills
• Excellent communications, problem-solving, analytical thinking skills
• Sees broader picture, impact on multiple programs, teams and/or departments
• Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency
• Emerging as an internal thought leader with technical and/or business expertise
• Applies in-depth knowledge of own area of expertise to solve problems
• Applies in-depth understanding and may guide others on how own discipline integrates within the department as well as impact to other departments and understands contribution to Neurocrine’s achievement of business objectives
• Experience with cutting edge antibody modeling software and structure-based engineering approaches a plus

Responsibilities

• Leads a protein engineering team in discovering, assaying, engineering, reformatting antibodies and biologics
• Responsible for resource allocation to achieve team and project goals within a defined budget
• Actively manage and develop a high performing team of protein engineers
• Develop and deliver scientific presentations, prepare clear and concise technical reports, participate or lead project teams
• Contributes to development of policies, SOPs, and department strategies
• Monitor and incorporate the latest developments in the biologic therapeutic space for opportunities that will keep Neurocrine’s franchises current and competitive
• Presents data and strategies at varying levels across the company
• Other duties as assigned

Preferred Qualifications

• Experience with cutting edge antibody modeling software and structure-based engineering approaches a plus