Sr. Scientist – Screening & Compound Profiling
| Company | MSD |
|---|---|
| Location | Linden, NJ, USA |
| Salary | $114700 – $180500 |
| Type | Full-Time |
| Degrees | |
| Experience Level | Mid Level, Senior, Expert or higher |
Requirements
- Hands-on experience in the areas of cellular assay development with proficiency in high-content screening and image analysis using primary cultures and cell lines
- Experience in development, execution and analysis of arrayed CRISPR screens
- Extensive development and miniaturization of cell-based assays (384w/ 1536w) using liquid handlers and detectors to support small molecule profiling
- Demonstrated ability to work under tight timelines and independently execute experimental tasks
- Guidance of scientific operations, strategy, and communication with a track record of collaboration on multidisciplinary teams in one or more therapeutic area(s)
- Passion for fostering a diverse and inclusive culture and contributing to the growth and success of colleagues
- Excellent verbal, written and interpersonal communication skills with a proven track-record of maintaining strong relationships with stakeholders.
Responsibilities
- Design, plan and execute robust scientific research activities utilizing cell-based assays ‘at-scale’ to accelerate lead discovery in the identification of molecules and targets via small molecule and CRISPR screens
- Develop arrayed CRISPR screening applications in cell lines as well as complex disease-relevant models (primary cells, co-cultures, 3D culture)
- Focus on high throughput (HT)-complex cell models (3D, iPSC, co-culture systems) to enable the development of ‘assays at scale’
- Represent Screening & Compound Profiling on cross-functional project teams influencing strategic direction with data/progress updates & insight
- Contribute to a high-performance culture of inclusion, collaboration, engagement and self-accountability.
Preferred Qualifications
- Understanding and application of image and data analysis using both traditional methods as well as AI/ML
- Collaboration to identify, evaluate, and recommend novel and cutting-edge assay development strategies to drive programs in areas including, but not limited to, high throughput-complex cell models, Cell Painting, CRISPR and ML/AI.