Scientist

BS with 5+ years of relevant experience or an advanced degree with 3+ years of relevant academic or industry experience.
Expertise in neurodegenerative and neuroinflammatory disease and experience with cell- and animal-based disease models.
A track record of publications in neurodegenerative disease, neuroimmunology, immunology, and/or related areas.
Extensive experience with both in vivo and in vitro models and tools preferred.
Highly organized, collaborative, and effective working on teams.
Understanding of in vivo pharmacology and/or molecule biodistribution in rodents or NHPs.
Ability to work collaboratively to identify and execute key steps necessary to advance projects.
Ability to effectively develop and discuss experimental goals and research progress with scientists and stakeholders of varied backgrounds.
Excellent analytical and communication skills.

Run animal studies to assess compound pharmacokinetics using different administration approaches including subcutaneous, intravenous, and surgical ICV dosing.
Validate in vivo mouse models of neurodegeneration to measure target engagement and tease apart disease mechanisms.
Establish new animal protocols, manage AUPs, and coordinate studies in compliance with in vivo best practices.
Establish primary, immortalized, and/or iPSC-based cell cultures to test compounds or model neuroinflammatory mechanisms.
Measure compound exposure and changes in neuroinflammatory pathways in the CNS using ELISA or other similar approaches.
Provide support for externally run studies by communicating with vendors and collaborators.
Help design and execute experiments, analyze data, and clearly communicate results at internal and external meetings.
Interact in a matrixed, dynamic and cross-functional manner across the Rare and Neuroscience Therapeutic Area and research platforms.
Help guide new drug candidates from the early exploratory discovery stage to the clinic.