Principal Scientist – Cell-Free Protein Synthesis & Synthetic Biology
| Company | Generate Biomedicines |
|---|---|
| Location | Cambridge, MA, USA |
| Salary | $Not Provided – $Not Provided |
| Type | Full-Time |
| Degrees | Bachelor’s, Master’s, PhD |
| Experience Level | Senior, Expert or higher |
Requirements
- PhD or equivalent and a minimum of 8+ years of experience in a relevant life sciences field (biophysics, biochemistry, biological engineering, quantitative/synthetic biology, or related discipline); or Master’s degree in a scientific field of study and 14 years of related experience; or Bachelor’s degree in a scientific field of study and 16 years of related experience
- Demonstrated expertise in protein biochemistry including protein expression, purification, and assessment of protein biophysical properties
- Strong track record of critical thinking and scientific achievement as demonstrated by publications in scientific journals
- Ability to multitask while paying attention to priorities and utilize resources efficiently
- Strong interpersonal skills including verbal and written communication to work effectively within a collaborative work environment
Responsibilities
- Expand Generate’s efforts to integrate CFPS into our HTP screening and production workflows
- Lead part of the team efforts to optimize CFPS workflows using both experimental tools (strain engineering, protein biochemistry, synthetic biology) and theory (computational analysis, statistics, and ML-guided optimization)
- Work together with members of the IDGS team to implement CFPS-based screening workflows involving micro-automation, microfluidics, and microfabricated devices
- Work with production and analytics teams in the Protein Sciences department to optimize scaled-up workflows and implement characterization of CFPS-produced material
- Generate bold, creative, unconventional ideas, and be a point person for intellectual property and patent writing
- Strategic experiment planning, data interpretation, summarization, and presentation with minimal supervision are required
- Involvement in accelerating the discovery, engineering and characterization of novel biologics in pipeline programs
- Mentor and train scientists throughout the company
Preferred Qualifications
- Cross-functional experience in the protein therapeutics industry and engineering of therapeutic proteins are highly desired
- Experience with automated workflows and liquid handling robots is a plus
- Experience with in vitro display technologies is a plus
- Deep subject matter expertise and experience with implementation and optimization of cell-free protein synthesis
- Up-to-date knowledge and understanding of CFPS-relevant literature
- Experience including advancing protein therapeutics through discovery and early development
- Demonstrated experience in high-throughput experimental design and laboratory automation