Associate Scientist I
| Company | Kyowa Kirin North America |
|---|---|
| Location | La Jolla, San Diego, CA, USA |
| Salary | $Not Provided – $Not Provided |
| Type | Full-Time |
| Degrees | Bachelor’s |
| Experience Level | Senior, Expert or higher |
Requirements
- BS required, MA/MS preferred in a related scientific discipline.
- Knowledge and background in Immunology, Hematology-Oncology, Cancer Biology, or Rare Disease therapies is a plus.
- 8 years of hands-on experience and in-depth knowledge of cell and gene therapy techniques and in vitro assay development.
- Strong background in molecular biology, with practical experience in cloning, molecular analytical development, NGS, and gene editing.
- Expertise in cell culture methodologies, including work with cell lines, primary human cells, iPSCs, and HSCs.
- Proven experience in the development and characterization of cell therapy products, including HSCs, iPSCs, and/or CAR-T cells.
- Proficient in gene editing technologies, including CRISPR, base editing, prime editing, and transposase or recombinase-based editing.
- Extensive experience in the molecular characterization of cell therapies, with a strong preference for expertise in NGS.
Responsibilities
- Support Cell and Gene Therapy pipeline projects by working with Project Leads to generate plasmid vectors, engineered cell lines, protein and antibody.
- Contribute scientific and technical knowledge to project and support teams.
- Design, initiate, and optimize molecular, cell based, and analytical assays and methods to support Research, Technical Operations, and In Vivo Pharmacology teams.
- Collaborate and manage requests from cross functional teams to move projects from research to development.
- Serve as a Project Lead for technology themed projects if needed.
- Identify and evaluate new technologies.
- Maintain compliance with regulatory guidelines and internal standards.
- Prepare necessary documentation for project reviews (proposals, monthly, quarterly, annual, or study reports), patent applications, publications, and/or animal, biosafety, or human subject protocols.
- Present research at project meetings and efficiently record experiments and data in laboratory notebooks, databases and monthly reports.
Preferred Qualifications
- Experience in developing high-throughput screening platforms for cells, proteins, or antibodies is preferred.
- Background in antibody/protein engineering, protein production, and purification is highly preferred.
- Familiarity with CAR design, engineering, screening, and assay development is highly desirable.
- Experience in virus production, transduction, and analytics is a valuable plus.