Director – Antibody / Protein Engineering and Optimization

Director – Antibody / Protein Engineering and Optimization

Requirements

• PhD degree in a scientific discipline with 10+ years experience, or MS with 16+ years experience, or BS with 18+ years experience.
• 9 years of Industry experience required.
• 9 years of managerial experience required.
• Outstanding expertise and depth of knowledge within a scientific area. Keeps up with the up-to-date scientific advancement (e.g. competitive landscape, new technology, new research portfolio, and new partnership).

Responsibilities

• Set high standards for effectiveness of execution, and rigor of thought. Have in-depth and currently relevant knowledge of antibody / biologic based discovery, optimization/ engineering approaches using in silico computational approaches.
• Recognize and streamline for the most efficient ways of working is a high priority in this role, and have tremendous drive, motivation to deliver (and beat) team and program goals, while also pushing the boundaries to enhance discovery and optimization.
• Work closely with and strongly influence the internal Global Biologics teams such as wet lab discovery, NGS, AI/ML groups, to best strategize for and lead for change in establishment of the best feedback loop of discovery/optimization for therapeutics application of scientific expertise in the review of wet-lab and in silico data with team members.
• Design of maturation libraries for display platforms (affinity/ potency/ stability) leveraging datasets, experience, and state-of-the-art software to improve lead candidates.
• Contribute to continual deepening of the expertise through external network development, evaluating new opportunities in partnership with business development.
• Lead biologics programs from discovery to IND, integrating early research, progression through candidate nomination and selection.
• Detailed knowledge of full biologics process from discovery to pre-IND.
• Ambassador for the biologics department, scientifically inputting to the project teams.
• Exceptionally collaborative mindset with interact with internal /external groups for high efficiency and transparency to enable swift progression of molecules.
• Organizational leader who has accountability for the performance and results of the core research function with managerial responsibility of a group of skilled members.
• Use enterprise mindset with a broad view across the portfolio that informs resourcing and prioritization of programs under direct remit.
• Empowerment to lead a small team of highly qualified and skilled scientists in their mission to generate therapeutic biologics.
• Develop the next generation of organizational and project leaders, acting as a champion of new opportunities. Team-centric mindset, inspiring and growing team members, while serving as a role model and mentor.
• Responsible for effective resourcing within team to drive programs forward in and efficient manner.
• Lead team through in-lab presence, designing and efficiently executing discovery/optimization campaigns including affinity maturation, developability; technology development.
• Excellent knowledge of data analysis tools to ensure thorough evaluation of datasets and information based next step decisions.
• High level of diligence in all data tracking, uploading, and recording using data management systems within the department.
• Key involvement and due diligence for external interactions, collaborations and workflows where appropriate.
• Contribution to the preparation of patents, documentation for IND, and publications.

Preferred Qualifications

No preferred qualifications provided.