Head of Therapeutics

PhD or advanced degree in Biochemistry, Cell Biology, Molecular Biology, or a related discipline.
Minimum of 10+ years of firsthand industry experience in developing cancer therapeutics using engineered proteins delivered via gene therapy approaches including ‘first in class’ products as well as ‘best in class’ products
8+ years direct experience building, inspiring, and managing high-performing multidisciplinary teams in biopharma
Strategic thinker with deep expertise in advancing novel gene therapy drugs with a track record of having taken one or more drugs from white board to IND and clinical studies
Deep expertise in immuno-oncology drug development is strongly preferred
Strong track record of scientific productivity as evidenced by high-quality, impactful publications
Thrive in a collaborative team setting and be driven to be innovative in a high energy, small company environment
Ability to handle multiple workflows simultaneously and meet aggressive project timelines

Lead the Earli Therapeutics Team to develop and advance novel non-viral gene therapy approaches using the Earli platform for the treatment of cancer.
Drive high-level strategy to down-select specific candidates for clinical development and generate appropriate efficacy and safety data packages for regulatory submission
Ensure that innovation is coupled with scientific rigor to drive program development strategies
Work with cross functional team leads (Gene Regulation, Delivery, Translational Biology) to create and execute on research roadmap for clear no-go/go decisions under expedited timelines
Act as the primary stakeholder to drive and communicate milestones and timelines to other senior leaders within the company as well as to external collaborators and advisors
Inspire, develop and empower the therapeutics team as well as provide technical expertise/scientific guidance
Write technical sections for IND and other regulatory filings
Work with the Head of BD and CSO to establish external partnerships with key pharma collaborators and academic labs
Work with the CSO and SAB members/KOLs to develop Target Product Profiles (TPPs) for lead therapeutic programs and ensure alignment of pre-clinical development strategy with TPP