Post Doctoral Scholar – Cancer Institute
| Company | Penn State |
|---|---|
| Location | Hershey, PA, USA |
| Salary | $Not Provided – $Not Provided |
| Type | Full-Time |
| Degrees | PhD, MD |
| Experience Level | Junior, Mid Level |
Requirements
- PhD and/or MD degree or equivalent
- Substantial experience in relevant techniques, including processing human samples, mouse modeling, and in vitro functional studies
- At least one recent publication (within 2 years) as the first or second author in a peer-reviewed journal in the field of molecular cancer signaling, targeted therapy or immunobiology/immune-oncology
Responsibilities
- Independently design and perform experiments requiring highly specialized techniques in cancer cellular/molecular biology and cancer immunology
- Conduct *in vivo* studies using both immunocompromised and immunocompetent mouse models of cancer
- Perform molecular and cellular assays such as MTS viability assay, western blot, soft agar assay, cell invasion assay
- Conduct single cell analysis e.g. 10x Genomics Chromium, IsoPLexis IsoLight proteomics platforms
- Utilize molecular and cellular immunology methods and techniques
- Isolate and analyze tumor cells and tumor infiltrating lymphocytes
- Quantify gene expression by qRT-PCR and prepare samples for RNAseq and other genomics, proteomics and epigenomics profiling experiments
- Conduct translational studies involving archival and fresh human tumor biopsied tissues and cell lines, and establish preclinical cell lines using patient-derived xenografts (PDX) method
- Manage clinical-pathologic database on translational research projects involving patients’ tissue and blood samples
- Perform multicolor flow cytometry experiments
- Attend and present at lab meetings and external national/international conferences
- Perform manual or computer-assisted data analysis, including the use of bioinformatics software; accurately record procedures used and results obtained from all experiments conducted; summarize results as a primary or a co-author in the form of manuscripts targeted towards high-visibility research journals or posters targeted towards scientific conferences
- Assist in lab stewardship, which may include maintaining cell cultures, managing safety assessment documents and databases, maintaining lab and equipment, keeping accurate inventory of lab assets, ordering supplies, and follow-up on working conditions of lab equipment and usage
- Develop new techniques and protocols by consulting various sources (articles, faculty, manufacturers, etc.)
- Maintain professional growth and development by reading current research literature, attending courses, seminars, and presenting research at conferences
- Advise, educate and train other lab personnel on area(s) of expertise
Preferred Qualifications
- Expertise in cancer immunobiology/immunotherapy