Principal Scientist – Downstream Biologics Process R&D
| Company | Merck |
|---|---|
| Location | Linden, NJ, USA |
| Salary | $169700 – $267200 |
| Type | Full-Time |
| Degrees | Bachelor’s, Master’s, PhD |
| Experience Level | Senior, Expert or higher |
Requirements
- Ph.D. with 6+ years, MS with 8+ years, or BS with 10+ years of industry experience and background in Chemical/Biochemical engineering, or a related field
- Strong fundamental knowledge and subject matter expertise in downstream processing of biologics, recent advances, and challenges in the field
- Expertise in independently conducting and directing the design, execution, analysis, and documentation of all stages of purification process development
- Track record of accomplishments in downstream bioprocessing with a history of peer-reviewed publications and presentations
- Knowledge of biologics CMC development
- Adaptability and agility to prioritize and deliver complex objectives, often on tight timelines, in a rapidly changing environment
- Experience and aptitude to lead, work, and collaborate in internal and external cross-functional, matrixed teams
- Action-oriented, mindset for creativity; ability to take initiative, innovate, iterate and problem-solve
- Demonstrated commitment to coach and mentor staff to maximize talent development and utilization
- Excellent interpersonal and communication skills
Responsibilities
- As an impactful contributor, shape and realize innovation across the Biologics’ pipeline, strategy, and science
- Advance the pipeline by collaborating with cross-functional teams, from Research & Manufacturing, in a fast-paced, multidisciplinary environment
- Participate in or lead development of robust and scalable purification processes for biologics in different stages of clinical development, process characterization and regulatory filings for successful commercialization
- Advance downstream processes by improving efficiency and cost effectiveness through research and innovation, while assessing technologies and industry best practices
- Collaborate with academia, industry, and vendors to drive development and early adoption of novel process technologies
- Contribute to strategic initiatives; partner with senior leaders to set overall project strategy, and guide teams towards its execution
- Conceptualize, plan, and execute projects with effective organizational, prioritization and problem-solving skills
- Stay abreast of scientific and regulatory landscape; actively present (premier conferences), publish (peer-reviewed journals) and patent
- Represent BPR&D as a downstream bioprocess expert in internal, cross-functional project teams and external conferences/consortia
- Mentor and actively share expertise; guide career development; build strong, collaborative teams
- Champion compliance and safety; promote a culture of diversity, inclusion, and equity
Preferred Qualifications
- Leadership of CMC development teams
- Continuous biomanufacturing integrated with process-analytical technologies
- High-throughput experimentation, automation, and process control
- Knowledge of protein expression, analytics, conjugation chemistry and formulation
- Biophysical, mechanistic and facility modeling; statistical analysis, data-science, machine learning, artificial intelligence