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Process Chemistry Senior Principal Scientist – Synthetic Peptide Chemist
| Company | Vertex Pharmaceuticals |
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| Location | Boston, MA, USA |
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| Salary | $153600 – $230400 |
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| Type | Full-Time |
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| Degrees | Master’s, PhD |
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| Experience Level | Senior, Expert or higher |
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Requirements
- Strong expertise in organic synthesis, especially solid-phase peptide synthesis (SPPS)
- Developing and scaling-up solid phase and liquid phase chemistry
- Experience with reverse-phase and/or ion-exchange purification of small molecules or peptides
- Strong organizational and communication skills
- PhD 6-8 years of experience, or MS degree with 9 years or experience (or equivalent education and experience) in synthetic organic chemistry or peptide chemistry
- Experience managing external CROs/CMOs
- Experience independently planning, executing experiments, and interpreting analytical data (H/UPLC, NMR, MS, etc.)
Responsibilities
- Responsible for the synthesis, purification, and characterization of small organic compounds, peptides, and oligonucleotides under minimal supervision
- Manage relationships with external partners
- Identify and advocate for innovative synthetic strategies to project teams
- Collaborate with project teams in a cross-functional environment
- Author or contribute to technical documents including regulatory submissions, patents, and scientific papers
- Maintain a high level of expertise via relevant scientific and technical literature, and proactively apply new ideas to research projects.
Preferred Qualifications
- Experience in nucleic acid modifications and delivery of oligonucleotides are highly desirable
- Experience with small- and large-scale CS-Bio solid phase peptide synthesizers (CS136x, CS936, or equivalent) in non-GMP and GMP environments
- Experience with the synthesis, conjugation and purification of phosphorodiamidate morpholino oligomers (PMOs) is highly desired
