Process Development Engineer I – Synthetic and Bioconjugation Scale Up Technologies
| Company | Regeneron Pharmaceuticals |
|---|---|
| Location | Tarrytown, NY, USA |
| Salary | $79100 – $129100 |
| Type | Full-Time |
| Degrees | Bachelor’s, Master’s |
| Experience Level | Mid Level |
Requirements
- Bachelor’s degree with 3+ years proven experience or Master’s in chemical/biochemical engineering or a related field
- Hands-on experience with bioconjugation processes (lysine-based, cysteine-based, site-specific etc.)
- Practical knowledge of downstream purification techniques such as chromatography, ultrafiltration/diafiltration, membrane technologies etc.
- Experience with a variety of analytical characterization tools such as mass spectrometry, high-performance liquid chromatography (HPLC), UV spectroscopy, etc.
Responsibilities
- Working at the bench to design and develop scalable, robust and controlled GMP-ready bioconjugation and purification processes
- Collaborating with analytical groups within or outside the organization to establish supportive analytical characterization techniques
- Discussing plans and data in cross functional teams to evaluate processes and determine developmental goals and ensure integrated program success
- Proactively complying to lab safety and environmental safety expectations of both Regeneron and regulatory bodies such as Food and Drug Administration (FDA), Department of Transportation (DoT), etc.
- Using statistical design of experiments (DOE) to optimize bioconjugation processes including conjugation reactions, purification operations, and analytical characterization
- Partnering with External Manufacturing group and other key partners at Regeneron’s IOPS organization to provide technical assessment of CDMO’s intended for GMP production and successfully transferring processes with immediate, first-time success.
Preferred Qualifications
- Experience with antibodies in the bioconjugates space is highly preferable.