Scientist I – Protein Bioanalytical
| Company | Tessera Therapeutics |
|---|---|
| Location | Cambridge, MA, USA |
| Salary | $Not Provided – $Not Provided |
| Type | Full-Time |
| Degrees | Master’s, PhD |
| Experience Level | Entry Level/New Grad, Junior |
Requirements
- PhD + 0-2 years or MS + 5 years of industry experience in Analytical Chemistry or related discipline e.g., biochemistry, biotechnology or pharmaceutical science. Post-doc experience a plus.
- In-depth scientific knowledge and hands on technical expertise on LC-MS, LC-MS/MS, and chromatography methodologies and instrumentation.
- Experience in LC-MS based proteomics is required.
- Excellent knowledge and hands-on experience in proteomics sample preparation techniques such as immuno-protein/peptide enrichment and fractionation.
- Extensive experience in protein isolation and purification from in vivo samples, such as biofluid and tissues.
- Experience in targeted protein quantification with triple quadrupole instrument is a plus.
- Ability to work in a team orientated environment and conduct multiple laboratory and project tasks efficiently.
Responsibilities
- Developing LC-MS methods for characterization and quantitation of proteins in various biological matrices including biofluids, tissues, cells, and subcellular fractions.
- Design and execute proteomics experiments from sample preparation, LC-MS/MS operation to data analysis & interpretation.
- Establish, optimize, and maintain the workflow of proteomics studies.
- Discover and validate potential biomarkers for supporting preclinical and clinical programs.
- Write proteomic reports and contribute to regulatory documents for IND/CTA filings.
- Providing maintenance, quality control and troubleshooting of high-resolution mass spectrometer and UPLC systems.
Preferred Qualifications
- Post-doc experience a plus.
- Experience in method qualification and bioanalyses to support pre-clinical studies from experience working with small molecule LC-MS and bioanalyses for small molecule drugs.