Scientist II/Senior Scientist – Protein Sciences
| Company | Flagship Pioneering |
|---|---|
| Location | Cambridge, MA, USA |
| Salary | $Not Provided – $Not Provided |
| Type | Full-Time |
| Degrees | PhD |
| Experience Level | Mid Level, Senior |
Requirements
- PhD in structural biology, biochemistry, molecular biology, microbial ecology, or related field.
- 2-6+ years of industry experience in biotech or pharma companies, developing and executing screening assays. Highly relevant post-doc experience is welcome.
- Proven experience with molecular cloning, protein expression in bacterial, yeast, or mammalian systems, and protein purification.
- Excellent problem-solving skills and the ability to work collaboratively in a multidisciplinary environment.
- Strong communication and organizational skills, with a track record of successful project management and scientific documentation.
Responsibilities
- Design, clone, and express genes encoding proteins in various expression systems, ensuring high-yield production.
- Develop innovative protein constructs and engineered variants tailored for enhanced performance in ice nucleation applications.
- Purify proteins using advanced chromatography techniques and other purification methods to ensure high yield and stability.
- Characterize protein structure and function, including cellular localization, binding affinities, self-assembly properties, and thermal stability.
- Develop and execute ice nucleation assays to assess the efficiency and performance of novel proteins.
- Collaborate with materials scientists and engineers to integrate biologically derived materials into functional sustainable solutions.
- Document and communicate research findings through detailed reports, presentations, and publications.
- Supervise and train junior research associate(s), fostering a collaborative and high-performance research environment.
Preferred Qualifications
- A strong background in self-assembling proteins and protein-protein interactions is preferred.
- Experience developing and running ice nucleation assays, including assessing freezing temperatures and nucleation efficiency.
- Familiarity with structural characterization tools such as X-ray crystallography, NMR, or cryo-EM is a plus.
- Experience collaborating with and guiding CROs on out-sourced projects highly desirable.