Scientist/Sr. Scientist – LC-MS
| Company | Orbital Therapeutics |
|---|---|
| Location | Cambridge, MA, USA |
| Salary | $Not Provided – $Not Provided |
| Type | Full-Time |
| Degrees | Bachelor’s, Master’s, PhD |
| Experience Level | Mid Level, Senior |
Requirements
- Ph.D. in Analytical Chemistry, Biochemistry or related discipline with 3+ years of CMC related experience; B.S./M.S. with appropriate years of experience will be considered.
- Strong experience analyzing various sample types using chromatography (HPLC/UPLC) in multiple separation modes (reversed phase, ion exchange, etc.) and associated detection methods is required, especially mass spectrometry (MS) and charged aerosol detection (CAD).
- Hands-on method development and impurity characterization experience with Thermo Orbitrap LC/MS system and associated software usage is highly desired.
- Strong problem-solving skills and proven ability to work independently as well as in a team.
- Detail-oriented in assay execution and documentation.
Responsibilities
- Work as subject matter expert to develop new analytical methods to characterize RNA-based products and their delivery systems utilizing expertise in chromatography (HPLC/UPLC).
- Explore new techniques and technologies to provide analytical support of research and development at all stages.
- Participate in phase appropriate method transfer to third parties as necessary, including providing expertise and documentation (SOPs, technical reports, method qualification plans) to assist in method verification, qualification, and validation.
- Partner collaboratively with internal teams (process development, formulation development, research, preclinical manufacturing) to meet analytical development and routine testing needs.
- Lead, perform/guide troubleshooting when necessary.
- Oversee routine analytical testing and review data as well as perform routine testing when necessary.
- Operate and maintain HPLC and mass spectrometry instruments.
- Purchase and maintain analytical reagents and standards.
- Document and communicate results to team members and leaders.
- Approach analytical challenges creatively and help build up a cutting-edge analytical platform.
Preferred Qualifications
- Experience with RNA/oligos, lipid nanoparticles, and/or proteomics is strongly preferred.
- Familiarity with GxP principles for development, documentation, qualification is preferred.
- Familiarity with early product development stage is preferred.