Senior Director – Platform Technology Development & Therapeutic Innovation
| Company | Flagship Pioneering |
|---|---|
| Location | Cambridge, MA, USA |
| Salary | $Not Provided – $Not Provided |
| Type | Full-Time |
| Degrees | PhD |
| Experience Level | Senior, Expert or higher |
Requirements
- PhD in Biological Sciences, Biochemistry, Biophysics, or related field with 12+ years of relevant industry experience, including 5+ years in scientific leadership roles.
- Extensive experience in CRISPR and synthetic biology, including engineering complex mammalian systems and expanding synthetic biology toolsets.
- Deep expertise in phage display, combinatorial libraries (yeast, RNA display, SELEX, DEL), high-throughput screening, and assay development.
- Familiarity with structural biology, NGS technologies (PacBio and Illumina), and biophysical/cellular characterization methods.
- Proficiency in applying machine learning tools to protein engineering and data interpretation.
- Proven track record of leading cross-functional programs and mentoring teams within fast-paced, matrixed environments.
- Strong communication, problem-solving, and organizational skills, with a demonstrated ability to influence across technical and executive audiences.
Responsibilities
- Lead end-to-end development of therapeutic programs, from target identification to IND-enabling candidate nomination, leveraging and expanding Metaphore’s synthetic biology and protein engineering toolkits.
- Drive platform innovation by developing and optimizing technologies and workflows that enhance scalability, reproducibility, and translatability across discovery efforts.
- Translate strategic priorities into actionable scientific roadmaps in close collaboration with Platform leadership and Innovation teams.
- Serve as a thought leader and subject matter expert across synthetic biology, phage and display technologies, combinatorial libraries, and high-throughput assay development.
- Foster strong cross-functional partnerships with Discovery, Computational Science, Translational Science, and Operations teams to integrate data-driven approaches and machine learning into platform development.
- Recruit, mentor, and inspire a high-performing team of scientists; create a supportive, collaborative, and psychologically safe environment that enables individuals and teams to thrive.
- Ensure scientific excellence, data integrity, and operational efficiency through best practices in experimental design, documentation, and decision-making.
- Communicate project strategy, key milestones, and outcomes to stakeholders across the organization with clarity and influence.
- Manage external partnerships with CROs and academic collaborators as needed, ensuring alignment and quality of deliverables.
- Contribute to the development and protection of Metaphore’s intellectual property through platform and therapeutic innovations.
Preferred Qualifications
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No preferred qualifications provided.