Senior Scientist

Senior Scientist

Requirements

• Extensive expertise in NGS methods, products, and applications, with practical experience in large-scale genomic techniques, including whole genome sequencing, exome sequencing, target enrichment, RNA sequencing, and single-cell sequencing.
• Proficient in bioinformatics and bioinformatics tools, including genome alignment, mapping, variant calling, and annotation, with the ability to conduct analyses and effectively communicate requirements to bioinformaticians.
• Proficient in molecular biology techniques, including DNA purification, DNA quantification, and PCR.
• Excellent documentation, communication, and interpersonal skills, with strong proficiency in both written and spoken English, and a demonstrated ability to collaborate effectively within a team.
• Detail-oriented and efficient in fast-paced environments, with demonstrated technical expertise and scientific creativity.
• Skilled in independently solving complex, diverse problems using innovative thinking and collaborative approaches.
• Ability to influence the trajectory of projects by offering actionable solutions that are adopted by core teams and stakeholders.
• Independently manages routine work and seeks guidance on new assignments as needed.
• Leads the creation of technical and supporting documents for both internal and external use.

Responsibilities

• Lead the design and development of custom DNA-based applications and tests, focusing on next-generation sequencing (NGS) targeted enrichment products.
• Independently plan and execute experiments, analyze data, and leverage findings to enhance NGS products and applications.
• Drive process improvement initiatives to optimize production workflows for NGS kits and Target Enrichment Panel lines, ensuring increased efficiency, quality, and scalability.
• Innovate and refine commercial kits and components, including formulations and protocols.
• Collaborate closely with bioinformaticians for data analysis and coordinate with internal Twist teams, including product management, manufacturing, and QC, on cross-functional projects.
• Ensure compliance with regulatory standards and ISO 13485 guidelines.

Preferred Qualifications

• A master’s degree with 5-7 years of experience or a PhD with 2-5 years of post-graduate experience in a related field such as molecular biology, biochemistry, genetics, genomics, or chemistry.
• Experience with an NGS company and in developing products for commercial launch is highly desirable.
• Coding skills in R, Python or equivalent languages.
• Experience with liquid handling systems and automation.