Posted in

Senior Scientist I – Analytical Chemistry

Senior Scientist I – Analytical Chemistry

CompanyExelixis
LocationAlameda, CA, USA
Salary$116000 – $165500
TypeFull-Time
DegreesBachelor’s, Master’s, PhD
Experience LevelSenior

Requirements

  • Ph.D. in analytical chemistry or related discipline with zero or more years of chromatography experience related to drug discovery
  • MS in analytical chemistry or related discipline and a minimum of five years of chromatography experience related to drug discovery
  • BS in analytical chemistry or related discipline and a minimum of seven years of chromatography experience related to drug discovery
  • Equivalent combination of education and experience
  • Knowledge of automatic liquid handler/Robotics and related data processing software
  • Strong knowledge of small molecule separation by modern chromatographic techniques such as Reverse Phase LC/UPLC, LCMS and SFC
  • Strong knowledge of LC, LCMS and SFC instrumentation
  • Good interpersonal skills, flexibility and works well within a team environment
  • Excellent written and verbal communication skills

Responsibilities

  • Perform high throughput compound library purification using LCMS detection and automation software
  • Perform separation, purification, analysis and scale up purification of small molecule compounds from medicinal chemistry synthesis including chiral separation
  • Use chromatographic methods including HPLC/UPLC, LCMS and SFC to separate compounds with complex matrices (problem solving)
  • Ability to use automated liquid handler robots to perform sample preparation pre and post purification
  • Perform data analysis and prepare analysis report under supervision
  • Participate in group, project team and departmental research meetings
  • Maintain laboratory notebooks in accordance with company policies and practices
  • Comply with safe laboratory practices and EH&S guidelines

Preferred Qualifications

  • Experience using LCMS, UPLC and SFC in drug discovery setting
  • Experience with purification and characterization of small molecule compounds
  • Experience with automation for liquid handling processes