Senior Scientist I – Analytical Chemistry
Company | Exelixis |
---|---|
Location | Alameda, CA, USA |
Salary | $116000 – $165500 |
Type | Full-Time |
Degrees | Bachelor’s, Master’s, PhD |
Experience Level | Senior |
Requirements
- Ph.D. in analytical chemistry or related discipline with zero or more years of chromatography experience related to drug discovery
- MS in analytical chemistry or related discipline and a minimum of five years of chromatography experience related to drug discovery
- BS in analytical chemistry or related discipline and a minimum of seven years of chromatography experience related to drug discovery
- Equivalent combination of education and experience
- Knowledge of automatic liquid handler/Robotics and related data processing software
- Strong knowledge of small molecule separation by modern chromatographic techniques such as Reverse Phase LC/UPLC, LCMS and SFC
- Strong knowledge of LC, LCMS and SFC instrumentation
- Good interpersonal skills, flexibility and works well within a team environment
- Excellent written and verbal communication skills
Responsibilities
- Perform high throughput compound library purification using LCMS detection and automation software
- Perform separation, purification, analysis and scale up purification of small molecule compounds from medicinal chemistry synthesis including chiral separation
- Use chromatographic methods including HPLC/UPLC, LCMS and SFC to separate compounds with complex matrices (problem solving)
- Ability to use automated liquid handler robots to perform sample preparation pre and post purification
- Perform data analysis and prepare analysis report under supervision
- Participate in group, project team and departmental research meetings
- Maintain laboratory notebooks in accordance with company policies and practices
- Comply with safe laboratory practices and EH&S guidelines
Preferred Qualifications
- Experience using LCMS, UPLC and SFC in drug discovery setting
- Experience with purification and characterization of small molecule compounds
- Experience with automation for liquid handling processes