Senior Scientist-Targeted Lipid Nanoparticle Delivery
| Company | Regeneron Pharmaceuticals |
|---|---|
| Location | Tarrytown, NY, USA |
| Salary | $108300 – $176700 |
| Type | Full-Time |
| Degrees | Bachelor’s, Master’s, PhD |
| Experience Level | Senior |
Requirements
- Ph.D. and 0-2 years of relevant post-Ph.D. experience or a BS/MS and 8-10+ years of relevant experience
- Firm understanding of biological principles related to internalization, receptor trafficking, and ligand targeting
- In vitro and in vivo experience in nanocarrier development
- Direct experience with lipid nanoparticles (LNP)
- Ability to interface and work collaboratively between biologists and chemists
Responsibilities
- Performing in vitro and primary cell culture assays to characterize properties of targeting, internalization, potency, including multicolor flow cytometry (10+ colors), intracellular fluorescence microscopy, and reporter assays
- Conducting functional in vivo assays of delivery/efficacy, including multicolor flow cytometry, in vivo luminescence/fluorescence, and ISH-based techniques
- Determining the specific and generalizable rules of targeted LNPs for ongoing and future preclinical program antibodies and ligands
- Collaborating with chemistry teams to produce, test and screen formulation/conjugation changes in nanocarriers
- Developing and implementing medium throughput assays to screen antibodies in vitro and in vivo
- Interpreting and presenting results at group and departmental meetings
- Keeping up-to-date with relevant scientific literature and conferences
Preferred Qualifications
- Familiarity with alternative antibody formats