Senior Staff Engineer – Process Safety
| Company | Takeda |
|---|---|
| Location | Boston, MA, USA |
| Salary | $137000 – $215270 |
| Type | Full-Time |
| Degrees | Bachelor’s, Master’s, PhD |
| Experience Level | Senior, Expert or higher |
Requirements
- A Ph.D. degree with 3+ years of industry experience; an MS degree with 9+ years of industry experience; or a BS degree with 11+ years of industry experience. Degrees in Material Sciences, Chemical Engineering or Mechanical Engineering required.
- Previous experience in process safety in the pharmaceutical, agrochemical, fine chemical or related industry required.
- Experience in HAZOPs and/or PHAs required, with a proven ability to lead safety assessments using digital tools.
- Strong background in kinetic modeling and the use of mechanistic models for identifying critical safety limits in reaction chemistry, ideally for pharmaceutical or chemical processes.
- Knowledge of in silico process development and the application of predictive models for proactive safety interventions and process optimization.
Responsibilities
- Lead the process safety team & activities.
- Develop suitable workflows and fit for purpose, phase appropriate testing plans for: 1. The identification of potential hazards of reactive chemicals, chemical reactions and waste streams. 2. The chemical hazard evaluation for combustible powders. 3. Assessing material compatibility.
- Work with process chemists and engineers to perform a thorough evaluation of all known and potential hazards for the safe scale-up of chemical processes for preparing pharmaceutical intermediates and active products in both Takeda’s research and manufacturing facilities.
- Collect and integrate relevant process safety data (e.g., calorimetry, pressure build-up, off-gassing) into digital platforms for seamless data analysis and sharing, ensuring data complies with FAIR principles (Findable, Accessible, Interoperable, Reusable).
- Use thermokinetic software and in silico models to calculate critical process parameters, such as runaway reactions, Self Accelerating Decomposition Temperature (SADT), and Time to Maximum Rate under Adiabatic conditions (TMRad), driving proactive safety interventions.
Preferred Qualifications
- Previous experience with software packages for process safety prediction (e.g., AKTS, Aspen Plus, gPROMS) preferred, focusing on the prediction of thermal, chemical, and kinetic properties.
- Sound knowledge of current Good Manufacturing Practices (cGMP) preferred.
- Experience working in a pilot plant a plus.
- Previous experience with the use of contract facilities and managing technical transfers a plus.