Translational PKPD Modeling & DMPK – Oncology
| Company | AstraZeneca |
|---|---|
| Location | Waltham, MA, USA |
| Salary | $Not Provided – $Not Provided |
| Type | Full-Time |
| Degrees | Master’s, PhD |
| Experience Level | Senior |
Requirements
- Ph.D. in Modeling & Simulation, systems biology, quantitative pharmacology, pharmacometrics, chemical engineering, physics, pharmaceutical sciences, or applied mathematics, with 3+ years of relevant industry experience.
- Relevant industry experience in Modeling & Simulation, ideally in preclinical/translational setting with a focus on biologics, or a MS degree with proven industry experience.
- Experience in a project-facing role within pharmaceutical R&D.
- Shown expertise in preclinical/translational modeling and simulation, including PK, PKPD, and TKPD.
- Strong understanding of DMPK and pharmacology in drug discovery, with a track record of delivering results in a fast-paced environment.
- Proficiency with tools such as WinNonLin/Phoenix NLME, NonMem, Berkeley Madonna, MATLAB, and SimCYP.
- Excellent interpersonal, communication, and leadership skills, with a passion for collaborative problem-solving.
Responsibilities
- Represent Oncology DMPK, providing scientific leadership in cross-functional and external collaborations.
- Develop and use PKPD models to explore the effects of target and pathway modulation, defining candidate drug target profiles.
- Predict human dose and regimen, contributing to exposure and pharmacodynamic biomarker-based decision-making for early clinical trials.
- Drive learning through back-translation of clinical exposure and pharmacodynamic data, offering strategic options for future clinical testing.
- Lead and participate in strategic scientific initiatives, continuous improvement projects, and external collaborations with academic or pre-competitive groups.
- Mentor students and postdoctoral fellows, contributing to the next generation of scientific talent.
- Present findings through publications, patents, and lectures, enhancing the visibility of AstraZeneca’s translational research.
Preferred Qualifications
-
No preferred qualifications provided.